Publications

Dominantly Inherited Alzheimer’s Disease: Colombia-Boston (COLBOS)

Fox-Fuller JT, Torrico-Teave H, d’Oleire Uquillas F, Chen K, Su Y, Chen Y, Brickhouse M, Sanchez JS, Aguero C, Jacobs HIL, Hampton O, Guzmán-Vélez E, Vila-Castelar C, Aguirre-Acevedo DC, Baena A, Artola A, Martinez J, Pluim CF, Alvarez S, Ochoa-Escudero M, Reiman EM, Sperling RA, Lopera F, Johnson KA, Dickerson BC, Quiroz YT. Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer’s disease: A cross-sectional study. Alzheimers Dement (Amst). 2021 Sep 14;13(1):e12233. doi: 10.1002/dad2.12233. PMID: 34541287; PMCID: PMC8438687.


Ghisays V, Lopera F, Goradia DD, Protas HD, Malek-Ahmadi MH, Chen Y, Devadas V, Luo J, Lee W, Baena A, Bocanegra Y, Guzmán-Vélez E, Pardilla-Delgado E, Vila-Castelar C, Fox-Fuller JT, Hu N, Clayton D, Thomas RG, Alvarez S, Espinosa A, Acosta-Baena N, Giraldo MM, Rios-Romenets S, Langbaum JB, Chen K, Su Y, Tariot PN, Quiroz YT, Reiman EM; API ADAD Colombia Trial Group. PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer’s disease-causing Presenilin-1 E280A mutation carriers. Neuroimage Clin. 2021;31:102749. doi: 10.1016/j.nicl.2021.102749. Epub 2021 Jul 4.PMID: 34252876. 


Martinez JE, Pardilla-Delgado E, Guzmán-Vélez E, Vila-Castelar C, Amariglio R, Gatchel J, Aguirre-Acevedo DC, Bocanegra Y, Baena A, Henao E, Tirado V, Muñoz C, Giraldo-Chica M, Lopera F, Quiroz YT. Subjective Cognitive Decline and its Relation to Verbal Memory and Sex in Cognitively Unimpaired Individuals from a Colombian Cohort with Autosomal-Dominant Alzheimer’s Disease. J Int Neuropsychol Soc. 2021 Jun 30: 1-9. doi: 10.1017/S1355617721000801. Online ahead of print. PMID: 34187609.


Pardilla-Delgado E, Torrico-Teave H, Sanchez JS, Ramirez-Gomez LA, Baena A, Bocanegra Y, Vila-Castelar C, Fox-Fuller JT, Guzmán-Vélez E, Martínez J, Alvarez S, Ochoa-Escudero M, Lopera F, Quiroz YT. Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer’s disease. Brain Commun. 2021 May 10;3(2): fcab101. doi: 10.1093/braincomms/fcab101. eCollection 2021.PMID: 34095834. 


Guzmán-Vélez E, Zetterberg H, Fox-Fuller JT, Vila-Castelar C, Sanchez JS, Baena A, Garcia-Ospina G, Aguillon D, Pardilla-Delgado E, Gatchel JR, Sperling RA, Johnson K, Reiman EM, Blennow K, Lopera F, Quiroz YT. Associations between plasma neurofilament light, in vivo brain pathology, and cognition in non-demented individuals with autosomal-dominant Alzheimer’s disease. Alzheimer’s & dementia: the Journal of the Alzheimer’s Association. 2021 February 1. PubMed PMID: 33527648; DOI: 10.1002/alz.12248.


Sanchez JS, Becker JA, Jacobs HIL, Hanseeuw BJ, Jiang S, Schultz AP, Properzi MJ, Katz SR, Beiser A, Satizabal CL, O’Donnell A, DeCarli C, Killiany R, El Fakhri G, Normandin MD, Gómez-Isla T, Quiroz YT, Rentz DM, Sperling RA, Seshadri S, Augustinack J, Price JC, Johnson KA. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography. Science translational medicine. 2021 January 20;13(577). PubMed PMID: 33472953; PubMed Central PMCID: PMC7978042; DOI: 10.1126/scitranslmed.abc0655.


Sanchez JS, Hanseeuw BJ, Lopera F, Sperling RA, Baena A, Bocanegra Y, Aguillon D, Guzmán-Vélez E, Pardilla-Delgado E, Ramirez-Gomez L, Vila-Castelar C, Martinez JE, Fox-Fuller JT, Ramos C, Ochoa-Escudero M, Alvarez S, Jacobs HIL, Schultz AP, Gatchel JR, Becker JA, Katz SR, Mayblyum DV, Price JC, Reiman EM, Johnson KA, Quiroz YT. Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study. Alzheimer’s research & therapy. 2021 January 15;13(1):27. PubMed PMID: 33451357; PubMed Central PMCID: PMC7811244; DOI: 10.1186/s13195-020-00765-5.


Armstrong GW, Kim LA, Vingopoulos F, Park JY, Garg I, Kasetty M, Silverman RF, Zeng R, Douglas VP, Lopera F, Baena A, Giraldo M, Norton D, Cronin-Golomb A, Arboleda-Velasquez JF, Quiroz YT, Miller JB. Retinal Imaging Findings in Carriers With PSEN1-Associated Early-Onset Familial Alzheimer Disease Before Onset of Cognitive Symptoms. JAMA Ophthalmol. 2021 Jan 1;139(1):49-56. doi: 10.1001/jamaophthalmol.2020.4909. PMID: 33180114; PMCID: PMC7662482.


Bocanegra Y, Fox-Fuller JT, Baena A, Guzmán-Vélez E, Vila-Castelar C, Martínez J, Torrico-Teave H, Lopera F, Quiroz YT. Association Between Visual Memory and In Vivo Amyloid and Tau Pathology in Preclinical Autosomal Dominant Alzheimer’s Disease. Journal of the International Neuropsychological Society: JINS. 2021 January;27(1):47-55. PubMed PMID: 32762790; DOI: 10.1017/S1355617720000673.


Baena A, Bocanegra Y, Torres V, Vila-Castelar C, Guzmán-Vélez E, Fox-Fuller JT, Gatchel JR, Sánchez J, Pluim CF, Ramirez-Gómez L, Martínez J, Pineda D, Lopera F, Quiroz YT. Neuroticism Is Associated with Tau Pathology in Cognitively Unimpaired Individuals with Autosomal Dominant Alzheimer’s Disease. J Alzheimers Dis. 2021;82(4):1809-1822. doi: 10.3233/JAD-210185. PMID: 34219716.


Vannini P, Hanseeuw BJ, Gatchel JR, Sikkes SAM, Alzate D, Zuluaga Y, Moreno S, Mendez L, Baena A, Ospina-Lopera P, Tirado V, Henao E, Acosta-Baena N, Giraldo M, Lopera F, Quiroz YT. Trajectory of Unawareness of Memory Decline in Individuals With Autosomal Dominant Alzheimer Disease. JAMA Netw Open. 2020 Dec 1;3(12):e2027472. doi: 10.1001/jamanetworkopen.2020.27472. PMID: 33263761; PMCID: PMC7711319.


Vila-Castelar C, Muñoz N, Papp KV, Amariglio RE, Baena A, Guzmán-Vélez E, Bocanegra Y, Sanchez JS, Reiman EM, Johnson KA, Sperling RA, Lopera F, Rentz DM, Quiroz YT. The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease. Alzheimer’s research & therapy. 2020 September 10;12(1):104. PubMed PMID: 32912283; PubMed Central PMCID: PMC7488408; DOI: 10.1186/s13195-020-00671-w.


Guzmán-Vélez E, Martínez J, Papp K, Baena A, Vila-Castelar C, Artola A, Schultz AP, Bocanegra Y, Sanchez J, Rentz D, Tariot PN, Reiman EM, Sperling R, Johnson KA, Lopera F, Quiroz YT. Associative memory and in vivo brain pathology in asymptomatic presenilin-1 E280A carriers. Neurology. 2020 September 8;95(10):e1312-e1321. PubMed PMID: 32611637; PubMed Central PMCID: PMC7538214; DOI: 10.1212/WNL.0000000000010177.


Norton DJ, Parra MA, Sperling RA, Baena A, Guzman-Velez E, Jin DS, Andrea N, Khang J, Schultz A, Rentz DM, Pardilla-Delgado E, Fuller J, Johnson K, Reiman EM, Lopera F, Quiroz YT. Visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant Alzheimer’s disease. Alzheimers Res Ther. 2020 Aug 21;12(1):99. doi: 10.1186/s13195-020-00660-z.PMID: 32825838. 


Quiroz YT, Zetterberg H, Reiman EM, Chen Y, Su Y, Fox-Fuller JT, Garcia G, Villegas A, Sepulveda-Falla D, Villada M, Arboleda-Velasquez JF, Guzmán-Vélez E, Vila-Castelar C, Gordon BA, Schultz SA, Protas HD, Ghisays V, Giraldo M, Tirado V, Baena A, Munoz C, Rios-Romenets S, Tariot PN, Blennow K, Lopera F. Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer’s disease kindred: a cross-sectional and longitudinal cohort study. The Lancet. Neurology. 2020 June;19(6):513-521. PubMed PMID: 32470423; PubMed Central PMCID: PMC7417082; DOI: 10.1016/S1474-4422(20)30137-X.


Gatchel JR, Lopera F, Norton DJ, Baena A, Guzman-Velez E, Sanchez JS, d’Oleire Uquillas F, Schultz A, Vannini P, Artola A, Amariglio RE, Rentz DM, Tariot PN, Reiman EM, Johnson KA, Sperling RA, Marshall GA, Quiroz YT. Association of subjective cognitive decline with markers of brain pathology in preclinical autosomal dominant Alzheimer’s disease. Journal of neurology, neurosurgery, and psychiatry. 2020 March;91(3):330-332. PubMed PMID: 31874859; DOI: 10.1136/jnnp-2019-321205.


Vila-Castelar C, Guzmán-Vélez E, Pardilla-Delgado E, Buckley RF, Bocanegra Y, Baena A, Fox-Fuller JT, Tirado V, Muñoz C, Giraldo M, Acosta-Baena N, Rios-Romenets S, Langbaum JB, Tariot PN, Lopera F, Reiman EM, Quiroz YT. Examining Sex Differences in Markers of Cognition and Neurodegeneration in Autosomal Dominant Alzheimer’s Disease: Preliminary Findings from the Colombian Alzheimer’s Prevention Initiative Biomarker Study. Journal of Alzheimer’s disease: JAD. 2020;77(4):1743-1753. PubMed PMID: 32925067; DOI: 10.3233/JAD-200723.


Arboleda-Velasquez, J.F., Lopera, F., O’Hare, M. et al. Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report. Nat Med (2019) doi:10.1038/s41591-019-0611-3


Ramirez-Aguilar L, Acosta-Uribe J, Giraldo MM, Moreno S, Baena A, Alzate D, Cuastumal R, Aguillón D, Madrigal L, Saldarriaga A, Navarro A, Garcia GP, Aguirre-Acevedo DC, Geier EG, Cochran JN, Quiroz YT, Myers RM, Yokoyama JS, Kosik KS, Lopera F. Genetic origin of a large family with a novel PSEN1 mutation (ILE416THR). Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. 2019; 14 (5): 709-719


Torres VL, Vila-Castelar C, Bocanegra Y, Baena A, Guzmán-Vélez E, Aguirre-Acevedo DC, Tirado V, Munoz C, Henao E, Moreno S, Giraldo M, Acosta N, Rios Romenets S, Langbaum JB, Cho W, Reiman EM, Tariot PN, Rosselli M, Quiroz YT, Lopera F. Normative data stratified by age and education for a Spanish neuropsychological test battery: Results from the Colombian Alzheimer’s prevention initiative registry. Applied neuropsychology. Adult. 2019 June 23:1-15. PubMed PMID: 31230490; PubMed Central PMCID: PMC6926163; DOI: 10.1080/23279095.2019.1627357.


Hanseeuw BJ, Lopera F, Sperling RA, Norton DJ, Guzman-Velez E, Baena A, Pardilla-Delgado E, Schultz AP, Gatchel J, Jin D, Chen K, Reiman EM, Johnson KA, Quiroz YT. Striatal amyloid is associated with tauopathy and memory decline in familiar Alzheimer’s disease. Alzheimers Res Ther. 2019; 11 (17): 1-6.


Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzmán-Vélez E, Jacobs HIL, Hanseeuw B, Pardilla-Delgado E, Artola A, Baena A, Bocanegra Y, Kosik KS, Chen K, Tariot PN, Johnson K, Sperling RA, Reiman EM, Lopera F, Quiroz YT. Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer’s Disease: A Comprehensive Review of the Colombian Kindred. J Alzheimer’s Dis 2018 Dec; 6: 1-9.


Guzmán-Vélez E*, Jaimes S*, Aguirre-Acevedo DC, Norton DJ, Papp KV, Rebecca Amariglio R, Rentz D, Baena A, Henao E, Tirado V, Muñoz C, Giraldo M, Sperling RA, Lopera F, and Quiroz YT. A Three-Factor Structure of Cognitive Functioning Among Unimpaired Carriers and Non-Carriers of Autosomal-Dominant Alzheimer’s Disease. J Alzheimer’s Dis 2018 Jun; 65: 107-115. doi: 10.3233/JAD-180078 *Contributed equally


Quiroz YT, Sperling RA, Norton DJ, Baena A, Arboleda-Velasquez JF, Cosio D, Schultz A, Lapoint M, Guzman-Velez E, Miller JB, Kim LA, Chen K, Tariot PN, Lopera F, Reiman EM, Johnson KA. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA Neurol. 2018 May 1;75(5):548-556. doi: 10.1001/jamaneurol.2017.4907.PMID: 29435558.


Norton DJ, Amariglio R, Protas H, Chen K, Aguirre-Acevedo DC, Pulsifer B, Castrillon G, Tirado V, Munoz C, Tariot P, Langbaum JB, Reiman EM, Lopera F, Sperling RA, Quiroz YT. Subjective memory complaints in preclinical autosomal dominant Alzheimer disease. Neurology. 2017 Oct 3;89(14):1464-1470. doi: 10.1212/WNL.0000000000004533. Epub 2017 Sep 6. PMID: 28878053; PMCID: PMC5631170.


Aguirre-Acevedo DC, Lopera F, Henao E, Tirado V, Muñoz C, Giraldo M, Bangdiwala SI, Reiman EM, Tariot PN, Langbaum JB, Quiroz YT, Jaimes F. Cognitive Decline in a Colombian Kindred With Autosomal Dominant Alzheimer Disease: A Retrospective Cohort Study. JAMA Neurol. 2016 Apr;73(4):431-8. doi: 10.1001/jamaneurol.2015.4851.


Quiroz YT, Schultz A, Chen K, Protas H, Brickhouse M, Fleisher AS, Langbaum JB, Thiyyagura P, Fagan AM, Shah AR, Muniz M, Arboleda-Velasquez JF, Munoz C, Garcia G, Acosta-Baena N, Giraldo M, Tirado V, Ramirez D, Tariot PN, Dickerson BC, Sperling RA, Lopera F, Reiman EM. Brain imaging and blood biomarker abnormalities in children with autosomal-dominant Alzheimer’s disease: A cross-sectional study. JAMA Neurol 2015 Aug 1; 72(8):912-919. doi: 10.1001/jamaneurol.2015.1099.


Quiroz YT, Willment KC, Castrillon G, Muniz M, Lopera F, Budson AE, Stern C. Successful scene encoding in presymptomatic early-onset Alzheimer’s disease. J Alzheimer’s Dis 2015; vol. 47, no. 4, pp. 955-964


Fleisher AS, Chen K, Quiroz YT, Jakimovich LJ, Gutierrez-Gomez M, Langois CM, Langbaum JBS, Roontiva A, Thiyyagura P, Lee W, Ayutyanont N, Lopez L, Moreno S, Munoz C, Tirado V, Acosta-Baena N, Fagan AM, Giraldo M, Garcia G, Huentelman MJ, Tariot PN, Lopera F, Reiman EM. Associations between biomarkers and age in the presenilin-1 E280A autosomal dominant Alzheimer’s disease kindred: a cross-sectional study. JAMA Neurol 2015; Jan 12. doi: 10.1001/jamaneurol.2014.3314.


Rodriguez R, Lopera F, Alvarez A, Fernandez Y, Galan L, Quiroz YT, Bobes MA. Spectral analysis of EEG in familial Alzheimer’s disease due to E280A presenilin-1 mutation. Int Alzheimer’s Dis 2014; 2014:180741.


Quiroz YT, Stern CE, Reiman EM, Brickhouse M, Ruiz A, Sperling RA, Lopera F, Dickerson BC. Alzheimer’s disease-signature cortical atrophy in presymptomatic AD presenilin-1 mutation carriers. J Neurol Neurosurg Psychiatry 2013; 84(5): 556-561


Reiman EM*, Quiroz YT*, Fleisher AS, Chen K, Velez-Pardo C, Jimenez-Del-Rio M, Fagan AM, Shah AR, Alvarez S, Arbelaez A, Giraldo M, Acosta-Baena N, Sperling RA, Dickerson BC, Stern CE, Tirado V, Munoz C, Reiman RA, Huentelman MJ, Alexander GE, Langbaum JBS, Kosik KS, Tariot PN, Lopera F. Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer’s disease in the presenilin 1 E280A kindred: a case-control study. Lancet Neurol 2012; 11(12):1048-1056. *Contributed equally


Fleisher AS, Chen K, Quiroz YT, Jakimovich LJ, Gomez MG, Langois CM, Langbaum JB, Ayutyanont N, Roontiva A, Thiyyagura P, Lee W, Mo H, Lopez L, Moreno S, Acosta-Baena N, Giraldo M, Garcia G, Reiman RA, Huentelman MJ, Kosik KS, Tariot PN, Lopera F, Reiman EM. Florbetapir PET analysis of amyloid-ß deposition in the presenilin 1 E280A autosomal dominant Alzheimer’s disease kindred: a cross-sectional study. Lancet Neurol. 2012 Dec; 11(12):1057-65.


Quiroz YT, Ally BA, Celone K, Mckeever J, Ruiz A, Lopera F, Stern CE, Budson AE. Event-related potential markers of brain changes in preclinical familial Alzheimer’s disease. Neurology 2011; 77(5): 469-475.


Quiroz YT, Budson AE, Celone K, Ruiz A, Castrillon G, Lopera F. Hippocampal hyperactivation in pre-symptomatic familial Alzheimer’s disease. Ann Neurol 2010; 68 (6): 865-875.


Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)

Rendon J, Zuluaga Y, Velilla L, Ochoa J, Arboleda-Velasquez JF, Budson AE, Lopera F, Quiroz YT. Event-Related Potential Correlates of Recognition Memory in Asymptomatic Individuals with CADASIL. Brain Research. March 2019; 1707: 74-78.


Schoemaker D, Quiroz TY, Torrico-Teave H, Arboleda-Velasquez JF. Clinical and research applications of magnetic resonance imaging in the study of CADASIL. Neurosci Lett. 2019. April 17;698:173-179. doi: 10.1016/j.neulet.2019.01.014


Zuluaga-Castaño Y, Montoya-Arenas DA, Velilla L, Ospina C, Arboleda-Velasquez JF, Quiroz YT, Lopera F. Cognitive performance in asymptomatic carriers of mutations R1031C and R141C in CADASIL. International Journal of Psychological Res. 2018; 11 (2): 46-55. Doi: 10.21500/20112084.3373


Primo V, Graham M, Bigger-Allen AA, Chick JM, Ospina C, Quiroz YT, Manent J, Gygi SP, Lopera F, D’Amore PA, Arboleda-Velasquez JF. Blood biomarkers in a mouse model of CADASIL. Brain Res. 2016 Aug 1; 1644:118-26. doi: 10.1016/j.brainres.2016.05.008.