Colombia-Boston biomarker study of autosomal dominant Alzheimer’s disease
COLBOS (COLombia-BOSton) is a collaborative project between the Universidad de Antioquia, Colombia and Massachusetts General Hospital, Boston. We work with an extraordinary kindred of approximately 6,000 individuals in Antioquia, Colombia, which contains roughly 1,500 carriers of an autosomal-dominant mutation (PSEN1 E280A). These carriers are genetically determined to develop early onset Alzheimer’s disease, with almost 100% certainty, and have a well-characterized disease course, with mild cognitive impairment (MCI) occurring at a median age of 44, and dementia at 49. We are currently in the longitudinal phase of our study, where we collect neuropsychological, biomarker and neuroimaging data from our participants about every two years.
Read more about what we have learned from this project here:
EARLY BRAIN CHANGES PREDICT ALZHEIMER’S DISEASE IN INDIVIDUALS AT GENETIC RISK