F31 NRSA Awardee: Joshua Fox-Fuller
Joshua Fox-Fuller was awarded a F31 NRSA from the National Institute on Aging to study working memory in preclinical Alzheimer’s disease (AD). His research relating to this award will gather new fMRI task-based data in the Colombian PSEN1 E280A Autosomal Dominant Alzheimer’s Disease (ADAD) cohort and will use other neuropsychological and neuroimaging data from the Colombian cohort and from the Harvard Aging Brain Study to look at 3 primary aims: (1) characterize working memory-related fMRI activation and connectivity in cognitively unimpaired ADAD mutation carriers and non-carriers; (2) investigate the relation between working memory, episodic memory, and Alzheimer’s Disease [AD] (PET) brain pathology in preclinical ADAD and sporadic AD; (3) examine the resting-state fMRI brain network integrity in working memory-related networks in preclinical ADAD and sporadic AD. In addition to working with the MAPP, Josh is co-mentored by Dr. Alice Cronin-Golomb through his PhD studies in clinical psychology at Boston University. This competitive pre-doctoral training mechanism will fund his remaining three years of predoctoral training, provides a training stipend, and provides funding to help expand his training-(e.g., conferences, workshops, equipment).