What will you be doing?
Participants will do memory and thinking tests performed with paper and pencil, as well as substance tests in their blood for genetic and biomarker studies. Blood is drawn for APOE genotyping and other plasma biomarkers related to Alzheimer’s disease, such as amyloid (plasma Aβ) and tau. The amyloid brain protein can be found using a drug called Pittsburgh Compound B (Pittsburgh Compound-B, PIB) during a Positron Emission Tomography (PET) brain scan. A Positron Emission Tomography (PET) is an imaging test that can show us proteins associated with Alzheimer’s disease in your brain. In addition to PIB, we want to use a marker in this study called [F-18] T807, which detects the tau protein in the brain. The tau protein, like the amyloid brain protein, is a biomarker for Alzheimer’s disease. We will also do Magnetic Resonance Imaging (MRI) scans so that any changes seen on PET scans can be compared to specific areas of activity and structures in your brain. An MRI uses a magnetic field to produce pictures of your brain.
Project activities may include:
- Personal health tracking
- Blood draw
- Office visit
- MRI scan
- PET scan
Estimated time commitment: 8 visits over 5 years
Compensation: Participants will receive up to $ 700 for completing all study procedures after 5 years