Your Brain: An Introduction to Its Anatomy
By: Rachel Kimball
Introduction:
Your brain is one of those things many of us take for granted. As the site of human consciousness, the coordinator of voluntary movement, and the regulator of nonconscious processes, your ? can do it all. The brain is not just a blob of cells in your skull, and the anatomy of the brain is quite complex. However, it is also very interesting to learn about.
Let’s start with some fun facts about the brain. Did you know…
– The average person has 12,000-60,000 thoughts a day
– The human brain triples in the first year of life and in adulthood, it gets smaller as we get older
– There are no pain receptors in the brain! The pain you feel from headaches are felt by the nerves in your head, face, and neck, NOT the brain. Headaches are triggered by chemical reactions caused by imbalances of neurotransmitters like serotonin, hormone imbalances, and changes in blood vessel constriction and dilation.
– There are one hundred billion neurons in the average brain 75% of the average brain is made of water
Let’s first dive into each lobe of the brain. Each lobe has its own set of distinct functions, and together, the lobes of the brain make you, you. Damage to the brain can result in serious complications, and learning the function/location of each lobe enables us to understand the consequences of brain damage.
Frontal Lobe:
Anatomy: The frontal lobes are located directly behind the forehead, and they are the largest lobes in the human brain. Located in the frontal lobe is Broca’s area, which controls the muscles in the mouth used for speech.
Function: The frontal lobe is responsible for speech & language production, motor skills, understanding & reacting to the feelings of others, forming personality, maintaining a sense of motivation, and managing attention.
Damage: The frontal lobes are the most common area for damage in the brain. It can result in paralysis, Broca’s Aphasia (inability to express language,) inability to focus, adynamia (reduced motivation), changes in personality, mood fluctuations, and difficulty controlling impulse.
Parietal Lobe:
Anatomy: The parietal lobe is located near the back/top of the head, directly behind the frontal lobe, and separated by the parieto-occipital central sulcus
Function: The parietal lobe is responsible for sensations, such as touch, pressure, pain, heat, and tension, navigating and controlling the body through spatial awareness, understanding written language, and solving math problems
Damage: Damage to the parietal lobe can result in difficulty in distinguishing left from right, spatial disorientation, alexia (problems with reading,) dyscalculia (difficulty with mathematics), and apraxia (difficulty with complex movements).
Occipital Lobe:
Anatomy: The occipital lobes are in the rear part of the upper brain. The central cerebral fissure divides the 2 lobes, and the tentorium cerebelli separates them from the temporal lobe and cerebellum. It contains the primary visual cortex, which sends and interprets information through our eyes
Function: The occipital lobe is responsible for depth perception, color determination, distance perception, face recognition, object recognition, and combing the images from both eyes into one image.
Damage: Damage to the occipital lobe can result in blindness and difficulty understanding basic colors & shapes, recognizing familiar faces, detecting moving objects, recognizing words, hallucinations, Riddoch syndrome (can’t see stationary objects,) and epilepsy.
Temporal Lobe:
Anatomy: The temporal lobes sit at the bottom middle portion of the brain, just behind the temples. Key structures include the auditory cortex and Wernicke’s area. The auditory cortex performs basic and higher functions of hearing and Wernicke’s area interprets written and spoken speech.
Function: They temporal lobe is responsible for long term memory, emotion, understanding and giving meaning to voices and sounds, and is an essential part of the limbic system.
Damage: Damage to the temporal lobe can result in impaired verbal memory, impaired musical skills, trouble with direction, deafness, auditory hallucination, impaired learning, life-threatening bleeding, dyslexia, Pick’s disease, and aphasia.
Cerebellum:
Anatomy: The cerebellum is found at the back & bottom of the brain, right behind the brainstem and under the occipital lobe.
Function: The cerebellum is responsible for maintaining balance, coordinating movement, assisting in vision and coordinates eye movements, motor learning & muscle memory, researchers think the cerebellum has some role in thinking and emotions.
Damage: Damage to the cerebellum can result in lack of muscle control and movement, abnormal eye movements, headaches, slurred speech or difficulty talking, difficulties with walking and mobility, ataxia, and dysmetria (inability to judge distance and know when to stop).
Brainstem:
Anatomy: The brainstem is divided into 3 sections: the midbrain (mesencephalon), the pons (metencephalon), and the medulla oblongata (myelencephalon).
Function: The brainstem is responsible for swallowing, breathing, vasomotor control (blood pressure) the senses – taste, smell, hearing, touch, sight, and controlling the heartbeat.
Damage: Damage to the parietal lobe can result in speech disorders,vestibular disturbance, dysphagia (difficulty or pain in swallowing) abnormal consciousness, demyelination (multiple sclerosis),infections, respiratory disturbance, vision problems, problems with other senses, and difficulty with vasomotor control.
Conclusion:
We hope you enjoyed using your brain to learn about your brain! Every part of the brain serves a different purpose which is why it is important for them to work effectively together. Damage to even just one lobe can lead to a decrease in performance and ability to perform certain tasks. We’ll be posting about brain injuries soon, so you can learn about ways to keep your brain safe and healthy.
Sources:
“Brainstem.” Encyclopædia Britannica, Encyclopædia Britannica, Inc., www.britannica.com/science/brainstem.
Johnson, Jon. “Hypothalamus: Function, Hormones, and Disorders.” Edited by Daniel Murrell , Medical News Today, MediLexicon International, 22 Aug. 2018, www.medicalnewstoday.com/articles/312628.
“Medical and Health Information.” Medical News Today, MediLexicon International, www.medicalnewstoday.com/.
Stamps, Caroline. Human Body. DK Publishing, 2013.
Healthcare Disparities: An Improvement in Equity Starts With Us
By: Rachel Kimball
Introduction:
After going to the emergency room, did insurance cover your bills? Have you had access to vaccines? Access to affordable prescribed medications? Have you been eligible to participate in clinical trials? Have you had access to affordable, safe housing and non-polluted air? Have you had access to nutritious food and clean water? Have you had a doctor listen to your symptoms thoroughly to provide an accurate diagnosis?
Unfortunately, these are questions that many Americans cannot say yes to. Having access to quality healthcare should be the norm, but why isn’t it?
Now, it’s possible this isn’t a problem that you personally face. However, you can play a role in combating it. The issues regarding healthcare disparities are the result of lack of compassion and a lack of education around these issues. Healthcare is vital for our survival, crucial for our existence. Yet, many of those who have access to it don’t care about the fact that others don’t! Ending this problem begins with acknowledging it, so let’s learn a little about healthcare inequity, so we can better educate ourselves and our peers.
Healthcare Disparities Overview:
The definition of healthcare disparities is “a particular type of health difference that is closely linked with social, economic, and/or environmental disadvantage. Health disparities adversely affect groups of people who have systematically experienced greater obstacles to health based on their racial or ethnic group, religion, socioeconomic status, gender, age, mental health, cognitive, sensory, or physical disability, sexual orientation or gender identity, geographic location, or other characteristics historically linked to discrimination or exclusion ” (2020 Healthy People).
It is important to note that healthcare disparities are not something that happen by chance, and as mentioned in this definition, healthcare disparities statistically affect marginalized groups of people more than others. Joan Quinlan, Vice President of Community Health at Massachusetts General Hospital states that “80% of one’s health status is attributable to a set of social and economic issues” (MGH Charged).
Examples of these attributable issues include a lack of the following: high-quality education, nutritious food, decent and safe housing, reliable public transportation, culturally sensitive healthcare providers, health insurance, clean water, and non-polluted air.
Preventing the factors that cause healthcare disparities is a start to ending the inequity surrounding healthcare. Although they may not seem related, things such as improving quality of education or providing affordable housing can greatly improve the healthcare of many.
Lack of trust in healthcare:
Harriet Washington, a medical ethicist and author of Medical Apartheid, states, “It is important for those of us in the medical community to gain awareness of the history because it provides a richer cultural context when engaging the African American community and our patients.” Although many of us are not professionals in the medical community, we are part of a community in which healthcare is crucial, and some of us may one day become healthcare professionals.
Unfortunately, the US has a long and complex history of medical experimentation on marginalized groups, and as Washington states, it is important to understand it, as it has led to a lack of trust in healthcare for many. Throughout history, medical schools disproportionately used African Americans in clinical trials and live surgical demonstrations. Additionally, for 40 years, from 1932 to 1972, the US Public Health Service (PHS) conducted an experiment on African American men who suffered from syphilis that led to slow and painful deaths.
This unfortunate history of prejudice and discrimination in clinical trials has led to a significant lack of trust. This is seen today in vaccine hesitation and a desire to seek medical treatment. Rebuilding this trust may be difficult, but it is important, as it has led to tremendous inequity in healthcare if some feel as though they are unable to trust the medical systems in place.
Implicit Bias in Medicine:
Implicit attitudes are thoughts and feelings that often exist outside of conscious awareness, and thus are difficult to consciously acknowledge and control.
Subtle biases towards patients of color may be expressed in several ways. This can include approaching patients with a dominant and condescending tone, failing to provide interpreters when needed, doing less thorough diagnostic work, recommending different treatment options, and allowing some families to visit patients after hours while limiting visitation for other families.
It is very dangerous for healthcare providers to have implicit bias, and due to the fact that it is implicit, it is often difficult to dismantle. Implicit bias is often learned from a young age, and the environments in which kids are brought up can greatly influence their opinions. Calling out bias and prejudice when you hear it, even among your adolescent peers, can make a difference, as many of them will one day be healthcare professionals. Likewise, if you hear those who are already healthcare professionals (your friends, family, or pediatricians) express bias, don’t be afraid to kindly call it out.
Lack of Representation in Clinical Trials:
First, socioeconomic status plays a significant role in eligibility of participating in clinical trials. In order to participate in a clinical trial, one must know that the trial is occuring in the first place. Those living in rural areas or those who don’t have access to internet are much less likely to know that the trials are occurring.
Second, due to the complex history of medical experimentation, many black Americans are rightfully hesitant to participate in these trials.
Third, due to underlying medical conditions and/or lack of education, many people are excluded from trials. For example, over 75% of black women have hypertension, compared to 40% of white women, and in most clinical trials, participants must have no underlying health conditions, such as hypertension. Furthermore, prior to participating in the trials, cognitive screening is performed. A lack of education or lack of English proficiency would cause potential participants to not reach the benchmark to participate. All of these factors result in a significant lack of representation in clinical trials.
It is important to note that clinical trials test potential treatments for the general public, and they often lead to incredible scientific discoveries. Every approved treatment and cure in medicine today once started with a clinical trial. However, when only a select demographic is included in the trials, it is unknown how the treatment would affect the actual population, a significant issue in healthcare today.
The Results of Inequity in Neurology & Psychiatry:
As mentioned in our Alzheimer’s Instagram/Blog posts, Alzheimer’s is a progressive disease. The later AD is diagnosed, the worse it is, and least likely it is to be reversed. Furthermore, AD isn’t the only progressive neurological disease, and most neurological diseases get worse with time, especially those left untreated.
Because people of color are unfortunately, less likely to seek care early on due to medical bias and the history of medical experimentation, it means that diagnoses are made further on in disease progression.
Conclusion:
Acknowledging that healthcare disparities are a problem is the first, but not only step needed to move forward. The NIH has stated that “Virtually absent in literature is evidence-based information on how to reduce an individual health care provider’s bias.” Therefore, it is critical that we point it out when we see it. We highly recommend listening to Joan Quinlan’s episode on MGH Charged to learn more!
Sources:
Hall, William J, et al. “Implicit Racial/Ethnic Bias Among Health Care Professionals and Its Influence on Health Care Outcomes: A Systematic Review.”
American Journal of Public Health, American Public Health Association, Dec. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4638275/. “National Healthcare Quality & Disparities Reports.” AHRQ,
www.ahrq.gov/research/findings/nhqrdr/index.html. “Scholar Speaks About History of Medical Experimentation on African Americans.” Scholar Speaks About History of Medical Experimentation on African Americans | UC San Francisco, www.ucsf.edu/news/2007/12/7682/scholar-speaks-about-history-medical-experimentation-african-american.
Siegel, Sari, et al. “Assessing the Nation’s Progress toward Elimination of Disparities in Health Care.” Journal of General Internal Medicine, Blackwell Science Inc, Feb. 2004, www.ncbi.nlm.nih.gov/pmc/articles/PMC1492147/.
Covid-19 Vaccines: How Can We Stop The Hesitation?
By: Adrianna Fusco; Rachel Kimball
*Please check out cdc.gov and talk with your healthcare provider for any questions regarding the COVID-19 Vaccine
*Note that this information is as of April 2021
Introduction:
Officially a year into the pandemic, COVID-19 has had a detrimental impact on our lives. We have all had a “Covid Birthday,” and what was once a “2-week closing” has turned into a very unprecedented time in our lives.
As the vaccine distribution begins to accelerate, the light at the end of the tunnel is becoming (slightly) more clear. However, one thing stands in the way: vaccine hesitation. Why are some hesitant to get vaccinated, and what can we do about it? It is important for us to inform ourselves about the science behind the vaccines, so we can encourage others to roll up their sleeves once they are eligible.
The Immune System:
In order to understand how vaccines work and why they are important, we must first understand the physiology of the immune system. The function of the immune system is to serve as a defense mechanism for our bodies against pathogens such as viruses, bateria, and parasites.
This process is sustained through two separate systems: the innate immune system and the adaptive immune system.
The innate immune system provides an immediate response to a pathogen invading the body, and when we are born, the innate immune system is almost completely developed. Physical barriers such as our skin, mucous, and hair are critical parts of the innate immune system, as they enable our body to fight off some pathogens immediately, before they even have a chance to enter our body. If pathogens are able to travel past these physical barriers, they can still be stopped in the bloodstream due to the complement system which sends fighter cells to pathogens to flag them as threats, causing pathogens to be wiped out before wreaking havoc.
While the innate immune system is incredibly important, the adaptive immune system is where vaccines play a role. The adaptive immune system is slower to respond than the innate system, but what sets it apart is its ability to “remember” pathogens. Once the adaptive immune system is introduced to a pathogen, the next time it encounters it, it will be able to better recognize and kill it. The adaptive immune system is made of T lymphocytes (T-Cells,) B lymphocytes (B-Cells,) and antibodies. Let’s talk about how the virus (Sars-CoV-2) turns into COVID-19.
Sars-CoV-2 → COVID-19:
Sars-CoV-2 stands for Severe Acute Respiratory Syndrome Coronavirus 2. This virus contains an RNA genome wrapped in a nucleocapsid and spike proteins. The lipid envelope is the outermost layer which protects the genetic information when traveling between host cells. It is important to note that this layer can be disrupted by soap and water. The spike proteins take on different shapes in different types of coronavirus, and this shape aids in Sars-CoV-2 cells latching onto Ace-2 Receptors in the human body, causing infection. Prior to immunity, there are no B-cells, T-cells, or antigens that can specifically target this virus, which allows the virus to “survive” its entire journey to those Ace-2 receptors, therefore, easily infecting humans who are not immune.
Let’s dive into the types of vaccines, so we can better understand the COVID-19 vaccines.
Types of Vaccines:
Vaccines are an important tool for preventing infection by acquiring immunity. There are 5 types of vaccines:
- Live Attenuated vaccines – use a weakened form of bacteria/virus for lifetime immunity.
- MMR, Rotavirus, Smallpox, Chickenpox, Yellow Fever
- Vector vaccines – use killed virus/bacteria
- Examples: Hepatitis A, Flu, Polio, Rabies
- Protein subunit vaccines: uses harmless pieces (proteins) of the virus/bacteria
- Hepatitis B, HPV, Shingles, Hib, Pneumococcal Disease
- Toxoids vaccines: based on toxin produced by virus or bacteria
- diphtheria, tetanus
- mRNA Vaccines: provide instructions
- Moderna and Pfizer COVID-19 vaccines
COVID-19 Vaccine Overview:
We previously learned that the adaptive immune system can prevent infection very effectively once you are vaccinated, as your body has a supply of T-Cells and B-Cells specifically designed for that virus ready to go, if needed, and this is exactly what the COVID-19 vaccine does. Once you are vaccinated, your body produces antibodies, T-Cells, and B-Cells, so when you are exposed to Sars-CoV-2, your immune system already knows how to deal with it.
The COVID-19 vaccines approved are Pfizer, Moderna, and Johnson & Johnson. Pfizer and Moderna are mRNA vaccines. Most vaccines (including the J&J Covid vaccine) contain pathogens so your body is immune to that virus. However, mRNA vaccines provide the instructions for your body to produce that virus or bacteria which then causes your immune system to develop a defense against it. mRNA is a single stranded molecule that exists in all of our cells, and enzymes in the cytoplasm translate that information to make the proteins.
COVID-19 Vaccine Efficacy
This chart highlights the differences between the 3 approved vaccines in the United States. Although there is a difference in effectiveness statistically speaking, the best vaccine to get is the one that is available to you first. The sooner you are vaccinated, the sooner you are immune.
COVID-19 Vaccine Concerns:
Q: How was the vaccine created so fast?
A: The vaccine was created using technology that was created and tested over many years. Moderna (which stands for Modified RNA) was established in 2010, 11 years ago! Vaccines usually take a while to test due to the lack of subjects for testing, but this was not a problem due to the urgency in finding a vaccine for COVID-19 and the willingness of participants to take part. Furthermore, many vaccines are mass produced after they are approved by the FDA to save money and resources in case the vaccine is not approved; however, the COVID-19 vaccines were produced prior to being approved, so when the vaccines were approved, there would already be a supply. The technology along with multitude of subjects and rapid production process lead to the quick creation. It is important to note that the “science” was not rushed in any way.
Q: Is the vaccine safe?
A: Yes, it is. For vaccines to become FDA certified, they must go through intensive and rigorous testing that involves thousands of people, which all 3 approved COVID-19 vaccines have. Long term effects appear 30 to 45 days after the 2nd dosage, and the FDA waited 60 days to pass the vaccines for emergency use, past the period in which severe long-term effects would have appeared.
Q: Can the vaccine alter my DNA?
A: No, the vaccine cannot alter your DNA. The vaccine uses RNA and creates protein based on the virus’s genes, not yours.
Q: When can children get the vaccine?
A: Right now the Pfizer vaccine is approved for age 16+, and the Moderna Vaccine is 18+. There have yet to be trials run on children, but according to Dr. Fauci, the trials are set to start in late January. The FDA is very careful when giving vaccines to children and pregnant women, and want to confirm the vaccines effectiveness
Q: Why shouldn’t I become immune naturally?
A: Attaining immunity naturally is risky and can lead to multiple health complications, and sometimes death. With COVID-19 people have reported having long term effects after contracting the disease and the death toll is large.Vaccines are more predictable and controllable than disease. The vaccines will give almost the same protection as natural immunity without the risks.
MAPP Teens’ Role in Combating Vaccine Hesitancy:
As MAPP Ambassadors, our goal is to promote brain health. But what do COVID-19 Vaccines and brain health even have in common?
First, COVID-19 can have long-term, devastating impacts on neurological function and the brain. For information about this, check out our “COVID-19 & The Brain” Instagram post from 1/18/21. Preventing these neurological complications requires preventing COVID-19, and the best way to do that is to get vaccinated.
Second, vaccine hesitation is a psychological issue, specifically, psychological constructs and ideologies. The most common forms of psychological constructs are conspiratorial and paranoid beliefs. Although “anti-vaxers” may seem like people who don’t believe in science, much of the time, vaccine hesitancy is the result of misinformation and paranoia.
Conclusion:
So now you know more about vaccines than the average person, but what do you do with this knowledge? The best way to combat vaccine hesitation is to educate others about the facts. In order for this pandemic to be over, a majority of the population must be vaccinated so we can reach herd immunity. Start by forwarding this article to others, and sending along information from the CDC.
The light at the end of the tunnel is there, but in order to reach it, we must reach herd immunity. So step in line, and roll up your sleeves as soon as you are eligible, then encourage others to do the same.
Works Cited
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Clem, A. (2011, January). Fundamentals of vaccine immunology. Retrieved January 12, 2021, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068582/#ref1
Coronavirus disease (COVID-19): Herd immunity, lockdowns and COVID-19. (2020, December 31). Retrieved January 12, 2021, from https://www.who.int/news-room/q-a-detail/herd-immunity-lockdowns-and-covid-19
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Herd immunity and COVID-19 (coronavirus): What you need to know. (2020, December 15). Retrieved January 12, 2021, from https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/herd-immunity-and-coronavirus/art-20486808
Kayla Hui, M. (2020, December 22). What’s in the COVID-19 Vaccines? Retrieved January 12, 2021, from https://www.verywellhealth.com/covid-19-vaccines-ingredients-lists-5093385
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Saplakoglu, Y. (2020, February 19). Coronavirus ‘spike’ protein just mapped, leading way to vaccine. Retrieved January 12, 2021, from https://www.livescience.com/coronavirus-spike-protein-structure.html#:~:text=Though%20the%20coronavirus%20uses%20many%20different%20proteins%
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Symptoms of Coronavirus. (2020, December 22). Retrieved January 12, 2021, from https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fabout%2Fsymptoms.html
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“Try Guys Debunk COVID Vaccine Conspiracies With Dr. Fauci.” YouTube, YouTube, 9 Jan. 2021, www.youtube.com/watch?reload=9&v=NDuaiYf8WDQ.
Viral envelope. (2021, January 09). Retrieved January 12, 2021, from https://en.wikipedia.org/wiki/Viral_envelope
*includes class resources like MiniPCR labs for COVID-19 genetics and COVID-19 vaccines
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Image by: Ridofranz
