January 22, 2021
Registration is closed
Note: times are U.S. Eastern Time
PROGRAM:
10:00-10:05am
Welcome, and opening remarks
Yakeel T. Quiroz PhD, Harvard Medical School
10:05-10:15am
APOE as a genetic risk factor for AD and neurodegeneration
Rik van der Kant PhD, Vrije Universiteit Amsterdam
10:15-10:45am
Mapping the metabolic landscape of glia in aging and APOE
Lance Johnson PhD, University of Kentucky
10:45-11:00am
Break
11:00-11:30am
Diminished effects of APOE4 on early Alzheimer’s disease phenotypes in non-Hispanic Blacks
Elizabeth Mormino PhD, Stanford University
11:30-12:00pm
APOE and vascular dysfunctions in both humans and animal models
Axel Montagne PhD, University of Edinburgh
12:00-12:30pm
Short Talks from Graduate Students
Apolipoprotein E4 moderates the association between cerebrovascular conductance and brain β-amyloid load
Carolyn S. Kaufman, University of Kansas Medical Center
Modulation of brain ApoE with selective siRNAs improves neuropathology in adult mice
Chantal M. Ferguson, University of Massachusetts Medical School
Cholesterol metabolism and inflammatory response is differentially regulated in APOE isogenic iPSC-astrocytes
Sherida M. de Leeuw, University of Zurich
12:30-1:00pm
Break
1:00-1:30pm
Short Talks from Postdocs/ Early career investigators
Regional susceptibility to lipid dysregulation by APOE 4 allelic dosage in aged mice
André Miguel Miranda, University of Minho, Portugal.
Dissociable effects of APOE-ε4 and β-amyloid pathology on visual working memory
Kirsty Lu, University College London, London, UK
APOE e4 modifies the balance between soluble and fibrillar B-amyloid in cognitively intact individuals
Raffaele Cacciaglia, Barcelona Beta Brain Research Center
1:30-2:00pm
Anti ApoE-HSPGs antibodies: Novel therapeutic interventions for Alzheimer’s disease
Claudia Marino PhD, Harvard Medical School
2:00-2:30pm
Lighting Presentation Rounds (see list below)
2:30-3:00pm
Uncovering cellular consequences of APOE variants
Priyanka Narayan PhD, NIH
3:00-3:30pm
MAPP APOE Award winners and closing remarks
Lighting Presentation Rounds
Gianna M. Fote. Investigation of mechanisms involved in Apolipoprotein E autophagic degradation and endocytosis.
Valentina Ghisays. Plasma Aβ42/40 ratios in cognitively unimpaired late middle-aged & older adult APOE ε4 homozygotes, heterozygotes, & non-carriers.
Nahdia S. Jones. High Fat Diet Induces Metabolic Disturbances in APOE4 mice and CNS Disturbances in APOE3 mice.
Maria Fe Lanfranco. Expression and secretion of ApoE isoforms in astrocytes and microglia after inflammation.
Cutler T. Lewandowski. Development of non-lipogenic ABCA1 inducers as multifunctional therapeutic candidates for Alzheimer’s disease.
Gemma Salvadó. The APOE-ε2 allele: effects on amyloid-β, tau and gray matter volumes.
Alexander Stuart. The influence of ApoE isoform on spatial memory and the hippocampal c-Fos response.
Vikram Venkatraghavan. Analyzing the effect of ApoE on Alzheimer’s disease progression using an event-based model for stratified populations.
Ellen Vromen. APOE ε4 dose-dependent alterations in CSF proteomics in prodromal Alzheimer’s Disease.
ApoE Symposium